Read With Us: The Antidote

Hello, Read With Us friends! If you're looking for a rich, surprising novel to spark deep conversation, psychological exploration, and food for the mind and soul, let me tell you a little bit about The Antidote by Karen Russell. Below are five compelling reasons why I think this book is a wonderful choice for our next read. 

Why I think this one deserves your time:

1. A haunting setting that blends history and magic.
The novel opens in the Dust Bowl era of the 1930s in a small Nebraskan town called Uz, already in collapse from drought, economic hardship, and historical erasure, and then a wild dust storm (on “Black Sunday”) lays bare the artificiality of the settlement, the cost of forgetting, and the fragility of memory. Russell layers in magical-realism (a “prairie witch” who stores memories, a time-travelling camera, a sentient scarecrow) to explore real themes of land-abuse, Indigenous erasure, and environmental collapse. For our book club, this means there’s both vivid story and rich metaphor: you’ll be reading a story of characters, while also talking about what the Dust Bowl means, what memory means, what our own era echoes.

2. Multi-layered characters whose stories interweave.
There’s Antonina (the “Prairie Witch” nicknamed the Antidote) who deposits other people’s memories; Harp Oletsky, the Polish-American farmer whose land miraculously thrives amid the drought; his niece Dell, a basketball-loving girl apprenticing under the witch; a Black photographer working for the New Deal whose camera shows more than meets the eye.  Because the novel moves among many viewpoints, we'll have plenty to talk about: whose story moved you most? Which viewpoint you found strongest or most compelling — and why.

Also interesting: the characters live with trauma, inheritance, place, and memory. After we read about someone leaving an abusive marriage in Nesting, you may especially appreciate how Russell handles trauma, memory, the “vaulting” of what we don’t want to remember.

3. Prose with ambition: beauty, strangeness, risk.
Russell is known for her inventive fiction (think Swamplandia!) and here she takes a big swing: the reviews talk about the “spell-binding” quality of her writing and how she uses metaphor and magical realism to make us think differently about American history. We are asking a bit more from you this time. For our book club, I think that’s a gift: you’ll find passages to re-read, lines to linger over, metaphors to unpack. I'm imagining that I might highlight how Russell describes dust, memory, wind, land, even basketball.

4. A narrative that connects to our time.
Though set in the 1930s, the book engages with themes still urgent today: climate collapse, settler amnesia, how we treat land, how we remember (and erase) history. For our Read With Us conversation, this means we won’t just ask “What happened?” but “What does this say about us now?” and “How does memory (personal, cultural, collective) tie into our lives today?”

5. Ideal for book-clubs because it offers both beauty and tension.
There’s tension: environmental disaster, murder, secrets, memory theft, going to the edges of what characters can hold. There’s beauty: language, character, strangeness, wonder. I think that mix can only add to our discussion. 

In an interview with BookPage, Karen Russell said she wanted to write a story where an apocalyptic future for us isn’t a foregone conclusion. “You can’t imagine a viable future, a world that’s kinder and more just than what we’ve got going today, without returning to the past,” Russell says. This sounds like a book for me. I've just started it and I'm finding it's not a book I can rush through, but it is a delicious read.

Kym, Carole, and I will be talking about the book, giving additional information, and doing promotional posts throughout November. Discussion day for The Antidote is scheduled for Tuesday, January 6, 2026 at 7:00 pm Eastern time, so mark your calendars. We'll ask questions on our blogs that day and then host the always fun, educational, and entertaining Zoom discussion.

Whether you're new to Karen Russell or already a fan, we hope you'll Read With Us and discover (or revisit since I know some of you have already read it) this amazingly creative novel. I think it's ambitious but readable, magical but grounded, beautiful but thought-provoking. It offers spectacle and depth, characters you’ll care about (and question), metaphors you’ll carry after the last page, in preparation for a discussion you'll be glad you had. I'm already looking forward to it and I hope you'll Read With Us!